Cystic Fibrosis Transmembrane Conductance Regulator

A chloride channel that regulates secretion in many exocrine tissues. Abnormalities in the CFTR gene have been shown to cause cystic fibrosis. (Hum Genet 1994;93(4):364-8)

Also Known As:

Protein, CFTR; Chloride channels, ATP-gated CFTR; Chloride channels, ATP gated CFTR; CFTR Protein

Amino Acids, Peptides, and Proteins: 1
- Proteins: 496323
  - Carrier Proteins: 13306
    - Membrane Transport Proteins: 606
      - Ion Channels: 6936
        Chloride Channels: 1813
        Cystic Fibrosis Transmembrane Conductance Regulator: 2843
      - ATP-Binding Cassette Transporters: 2910
        Multidrug Resistance-Associated Proteins: 701
        Cystic Fibrosis Transmembrane Conductance Regulator: 2843
      - Ion Pumps: 63
        Anion Transport Proteins: 2
        Organic Anion Transporters: 381
        ATP-Dependent Organic Anion Transporters
        Multidrug Resistance-Associated Proteins: 701
        Cystic Fibrosis Transmembrane Conductance Regulator: 2843
  - Membrane Proteins: 10262
    - Membrane Glycoproteins: 2277
      - Ion Channels: 6936
        Chloride Channels: 1813
        Cystic Fibrosis Transmembrane Conductance Regulator: 2843
    - Membrane Transport Proteins: 606
      - Ion Channels: 6936
        Chloride Channels: 1813
        Cystic Fibrosis Transmembrane Conductance Regulator: 2843
      - ATP-Binding Cassette Transporters: 2910
        Multidrug Resistance-Associated Proteins: 701
        Cystic Fibrosis Transmembrane Conductance Regulator: 2843
      - Ion Pumps: 63
        Anion Transport Proteins: 2
        Organic Anion Transporters: 381
        ATP-Dependent Organic Anion Transporters
        Multidrug Resistance-Associated Proteins: 701
        Cystic Fibrosis Transmembrane Conductance Regulator: 2843

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Disease

Drug/Important Bio-Agent (IBA)